SUMMARY:

Introduction: The anxiety is a present continuum in the general population and that quantitatively we called upheaval of anxiety generalized as of the moment at which disfuncional becomes. To distinguish the nonpathological anxiety of the pathological one the ability of the artist has left. Nevertheless a series of upheavals exists in which the anxiety changes qualitatively and a specific clinic and a biological marker are expressed fenotípicamente with like which we presented/displayed.
Objectives: To try to objetivar if significant changes in the answer of GH to GRF between general population, upheavals of generalized anxiety and upheavals of anguish exist comparativily.
Material and method: 224 tests of stimulation of GH with 1-2 m gr. by kg of intravenous weight of GRF(1-19)NH2 to general population, upheavals of generalized anxiety and upheavals of anguish were made using the selection of cases with criteria DSM and/or CIE.
The multiple linear regression was used like statistical test. The values of GH to the 0.15.30 and 60 minutes by means of IRMA were moderate.
Results: The test does not discriminate the upheavals of general anxiety of the general population, but to both of the anguish upheavals where objective a significant hypoanswer of GH in the different times.
Conclusions: the 1 hypoanswer of GH in the test that we presented/displayed could be a suction biological marker to greater criterion for the diagnosis of Upheaval of anguish. 2 the GH answer is similar in the general population and the upheavals of generalized anxiety.

INTRODUCTION:

The anxiety for the dynamic theoreticians is secondary to conflicts, although decades ago the father of these accepted in the final phase of his life a type of anguish that did not have relation with those. The anxiety this present in the general population because we suppose that she is the one that has conflicts; within the general population a group of people requests aid to mitigate the suffering that such conflicts generate and to this one suffering we called upheaval of anxiety generalized by consensus. Decades ago the noxología was confused and as the anxiety seems to be present in everything what it moves, the American school and the European invent its categoriales systems to distinguish the anxiety of the anguish. It does not have sense to repeat operative criteria that everybody knows. To distinguish the nonpathological anxiety of the pathological one the ability of the artist has left, to the quantification of diverse scales, the psicopatológica exploration. If the existence of a continuum between the anxiety-conflict of the general population had not been accepted and the anxiety conflict of the upheavals of generalized anxiety, we would propose that this outside accepted one without rechistar, simply quantitative changes would be objetivarían. Nevertheless a series of upheavals exists in which the anxiety changes qualitatively and a specific clinic and a biological marker are expressed fenotípicamente with like which we presented/displayed. Still a conceptual dispute to both sides of the pool exists that does not seem that it has solution. We would move in an arc between which they think that everything is biological, those that thinks that everything is conflict and the integrators of both theories, without the discussion has end. We do not try to solve the subject.

OBJECTIVES:

To try to objetivar if significant changes in the answer of GH to GRF between general population, upheavals of generalized anxiety and upheavals of anguish exist comparativily.

MATERIAL And METHOD:

224 tests of stimulation of GH with 1-2 m gr. by kg of intravenous weight of GRF(1-19)NH2 to general population, upheavals of generalized anxiety and upheavals of anguish were made using the selection of cases with criteria DSM and/or CIE.

The multiple linear regression was used like statistical test. The values of GH to the 0.15.30 and 60 minutes by means of IRMA were moderate.

RESULTS:

In tables 1 and 2 you are seen DAS distributions by sex and ages. In table graphical 3 and 1.2 and 3 the results of the tip of the growth hormone are reflected (GH), the area under the curve and the values of GH in the different times from the test. In the table 4 and graph 4 the results of the IGF are exposed 1.La test of GH stimulation after GRF does not discriminate the upheavals of general anxiety of the general population, but to both of the anguish upheavals where objective a significant hypoanswer of GH in the different times.

Table 1: Distribution by groups and sex:

Table 2: Age of the studied patients.

Table 3: Test resultses of GHRH.

Table 4: Summary of the IGF-1 levels.

DIFFERENCES IN GH And IGF 1 BETWEEN The GROUPS

In all the variables of GH (tip of GH, GH ABC, GH to the 0, 15, 30 and 60 minutes) an effect due to the property one of the groups was observed and another having exclusively to the age, and effect of other variables like sex was not observed, either saw effects of interaction nor confusion between variables.

Tip of GH (graphical 1)

Effect of the property to one of the groups: The GH tip was in the group distresses inferior to the controls in a 14,5 average ng/ml (p=0.0000, IC 95 %: 10,0 to 19,0 ng/ml). There were no differences between group generalized anxiety and group control.

Own effect of the age: by every year of life the tip of GH in 0.3 ng/ml of average diminished (p=0.0000, IC 95 %: 0,2 to 0,4 ng/ml). These data are despicable or of minimum influence. It would suppose for example in 20 6 years ng/ml than less average on the 14 present ones.

Area under the GH curve (ABC)(Gráfico 2)

Effects similar to the observed ones were seen on the GH tip:

Effect of the anguish: The GH ABC was in the group of inferior anguish to the group control in an average of 570,6 ng× min/ml (p=0.0000, IC 95 %: 330,3 to 810,9 ng× min/ml). There were no differences between group generalized anxiety and group control.

Own effect of the age: by every year of life ng× diminished the ABC of GH in 9.9 min/ml of average (p=0.001, IC 95 %: 3,9 to 15,9 ng× min/ml). Like in the GH tip, it is east despicable data. In 20 years ng× would diminish the ABC of GH in 200 min/ml of average on the 570 present ones.

GH to the 0 minutes: (graphical 3)

Effect of the anguish: in the anguish group ng/ml of average was inferior to the group control in 1.2 (p=0.02, IC 95 %: 0,2 to 2,3 ng/ml). There were no differences between group generalized anxiety and group control.

Own effect of the age: an effect own of the age, although very small was seen, that by every year of life diminished the basal GH in 0.03 ng/ml of average (p=0.01, IC 95 %: 0,01 to 0,06 ng/ml).

GH to the 15 minutes:

Effect of the anguish: in the anguish group ng/ml of average was inferior to the group control in 9.8 (p=0.0000, IC 95 %: 6,4 to 13,2 ng/ml). There were no differences between group generalized anxiety and group control.

Own effect of the age: an own effect of the age was seen, that by every year of life diminished the GH to the 15 minutes in 0.2 ng/ml of average (p=0.0003, IC 95 %: 0,1 to 0,3 ng/ml).

GH to the 30 minutes:

Effect of the anguish: in the anguish group ng/ml of average was inferior to the group control in 13.8 (p=0.0000, IC 95 %: 9,6 to 18,0 ng/ml). There were no differences between group generalized anxiety and group control.

Own effect of the age: by every year of life the GH to the 30 minutes in 0.2 ng/ml of average diminished (p=0.0000, IC 95 %: 0,1 to 0,3 ng/ml).

GH to the 60 minutes:

Effect of the anguish: in the anguish group ng/ml of average was inferior to the group control in 10.0 (p=0.0000, IC 95 %: 6,0 to 14,0 ng/ml). There were no differences between group generalized anxiety and group control.

Own effect of the age: an own effect of the age was seen, that by every year of life diminished the GH to the 60 minutes in 0.2 ng/ml of average (p=0.0000, IC 95 %: 0,1 to 0,3 ng/ml).

IGF-1: (Graphical 4)

Any effect was not observed to belong to some of the groups, nor of sex, but only of the age, being that by every year of life ng/ml diminished in 4.0 (p=0.0000, IC 95 %: 2,9 to 5,0 ng/ml).

Graphs 1: Tip of GH, imagines medium, cuartiles, maximum and minimum.

Graph 2: Area under the GH curve: medium, cuartiles, maximum and minimum.

Graph 3: Test of GHRH: they imagine medium, cuartiles, maximum and minimum to the different times.

Graph 4: IGF-1, imagine medium, cuartiles, maximum and minimum.

DISCUSSION:

It is forced to send to us to the reader to our previous works that we mentioned in the bibliography and which they are in the network. Theoretical ours constructo follows the same direction, although in this work we show the difficulties that the biological marker that we used plant in the diagnosis differential of psychic normality and the upheavals of generalized anxiety. We insisted on which to know if an anguish crisis happens in an upheaval of generalized anxiety or an upheaval of anguish it is not possible only with categoriales criteria and that need or of other biological markers. In another work we explained as the hypoanswer of the growth hormone is not exclusive of the anguish upheavals and as a phantom of psychiatric diagnoses exists that could be extending as they are studied, that is characterized by a severe anguish and that they present/display hypoanswer of GH after GRF; it léase alcoholism in first week of abstinence, depression and compulsive obsessive upheaval, among other possible candidates who the undergone reader could suggest in a future. We can conclude with: the 1 hypoanswer of GH in the test that we presented/displayed could be a suction biological marker to greater criterion for the diagnosis of Upheaval of anguish. 2 the GH answer is similar in the general population and the upheavals of generalized anxiety.

BIBLIOGRAPHY:

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