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Parametric analysis of the answer of the hormone of growth in population heals and depression

Porras Obeso Salvador * and Girbés Borrás Juan **. General Hospital of Elda-Alicante- Spain.

* Psychiatrist, **Endocrino and statistical analyst.

 

Pattern of answer of the GH to the stimulus with GHRH in the patients without psychiatric disease

 

Introduction.

The anomalous answer of the GH to the stimulus with GHRH has been related to the presence of some psychiatric pathologies, between which they are the anguish and the depression, in that would sublie a fisiopatológica alteration that would cause that the answer of the GH abnormally was reduced. It does not have, nevertheless, publications that suitably describe the behavior of the subject controls, since on general they are based on very few cases.

 

Objective.

To describe the behavior of the GH in answer to the stimulus with GHRH in people without somatic nor psychiatric pathology, with object to have a pattern of behavior with which to compare the answer of the ill subjects.

 

Material and Methods.

61 normal subjects without somatic nor psychiatric pathology studied, were 17 men and 44 women, with an average age of 36,4 years (D.E.19.3, minimum 13, maximum 81 years). To all the patients basal determination of GH and after stimulus of between 1-2 was made to them µg of GHRH i.v. by kilo of weight, to the 15, 30 and 60 minutes. The values for each point are detailed, by sexes, with average and standard deviation. One studied the possible dependency of sex and age by means of multiple linear regression. The behavior of the values of GH, the maximum tip, the area under the curve and the difference studies maximum value less basal value.

Results.

The results, in ng/ml and detailed like average (D.E.) to the different times they were the following ones: Basal GH: men 0,9 (0.8), women 2,0 (3.6); GH 15 minutes:  men 13,0 (9.6), women 17,6 (17.9); GH 30 minutes: men 14,2 (12.8), women 22,4 (20.1); GH 60 minutes: men 12,7 (13.0), women 16.9(19.2). The maximum value of GH was reached in 46 % of the cases to the 30 minutes, in 39 % to the 15 minutes and in 14 % to the 60 minutes. A homogenous behavior in the men was detected, but not in the women, so that as of the 40 years the answer descended clearly, reason why the effect of the age it studied after codification of the same one according to this one outside inferior one to 40 years or no. The multiple linear regression showed: Basal GH: no significant influence. Significant effect (p<0.01) of the age was observed solely, but not of sex, in the GH to the 15 and 60 minutes, as well as in the difference between the GH to the 30 minutes and basal and in the difference between the GH Maxima and the basal one. Significant effect (p<0.01) of the age and sex was observed, with interaction between age and sex (different behavior in both sexes according to the age) in GH to the 30 minutes, GH Maxima and area under the GH curve.

 

Conclusions.

-          The normal people respond with an increase of GH that is maximum between the 15 and 30 minutes in general.

-          The magnitude of the answer depends on the age and sex: the women of less than 40 years have an answer somewhat superior to the women from this age, and to the men in general. There are no differences between greater women of 40 years and men in this answer.

 

 

 

 

Dynamic study of the secretion of GH in the depression

 

Introduction.

Preliminary studies of our group, with few patients, had suggested, by means of nonparametric tests, a possible diminished answer of the GH to the stimulus with GHRH, in the patients with depression, in relation to the normal subjects. This could be, in the future, an analytical support in the diagnosis of this organization.

Objective.

To study and to quantify the difference in the answer of GH to the stimulus with GHRH between normal and subject subjects with depression.

Material and methods.

They study 6çontroles (17 men, 44 women), with an average age of 36,4 years (D.E.19.3, minimum 13, maximum 81 years), and 73 patients with depression (19 men, 54 women), with an average age of 43,6 years (D.E. 16,8, minimum 14, maximum 85), of which 22 (30,1 %) took some antidepressing treatment. To all the patients basal determination of GH and after stimulus with 100 was made to them µg of GHRH i.v., to the 15, 30 and 60 minutes. The possible influence of the depression by means of multiple linear regression studied, being the dependent variable the GH to the different times, to the GH Maxima, the area under the curve, the difference between the GH to the 30 minutes and basal or the difference between the GH Maxima and the basal one. As variable predicting they were included, in addition to the presence of depression, the age (codified like inferior or not to 40 years), sex and the ingestion of some antidepressant.

Results.

The taking of some antidepressing treatment did not show significant influence on any of the values of GH. Sex and age stayed in the model of multiple regression to present/display significant influence, and to avoid possible effects of confusion. Significant influence of the depression presence was observed on the values of GH the 15 and 30 minutes, and on the difference between GH to the 30 minutes and the basal GH (p<0.05). Significant difference was not observed on basal GH, GH to the 60 minutes, area under the GH curve and difference between basal GH Maxima and.

 

Conclusions.

The behavior of GH in answer to GHRH is different in depressive and controls, presenting/displaying a first answer slightly diminished. This insufficient answer has been significant for the values to the 15 and 30 minutes, as well as in the increase observed between the 0 and 30 minutes in the same patient. It is about to to see if this observation can have practical application in the future.

 

 

 

More than text, the numbers, tables, graphs they will be connected shortly De moment the summary so that the mathematics applied to the clinical-analytical observation are not choked.

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