Table 1 shows the characteristics of each group: sex and age. They took to some antidepressing treatment 22 patients: 7 men and 15 women of the group of depressive patients.

Table 1. Age and sex of the patients by sub-groups. The descriptive data (average, medium, desv. standard, minimum and maximum) talk about the age and are expressed in years. n indicates the so large sample.

Group	Sex	n	Average	Medium	D.E.	Mín.	Máx
Depression	Men	19	45.6	39	16.7	18	85
	Women	54	42.8	43	16.9	14	75
	Total group depression	73	43.6	42	16.8	14	85
Control	Men	17	42.5	32	24.0	15	81
	Women	44	33.8	32	16.6	13	70
	Total group control	61	36.4	32	19.3	13	81

The possible influence of the depression on the GH answer studied by means of multiple linear regression. They were introduced as variable indendientes the presence of depression, age, sex and is present at of some antidepressing treatment. As variable employee introduced the value of GH to the different times, the maximum value of GH in the test and the area under the curve. Interactions of taken variables two to two were introduced in the model. The area under the curve calculated by the procedure of the trapezes.

Tabla 2. GH basal.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	0.9	0.8	0.8	0.2	2.5
	Mujer	44	2.0	0.6	3.6	0.2	19.2
	Subtotal	61	1.7	0.6	3.1	0.2	19.2
Depresión	Hombre	19	0.5	0.3	0.6	0.2	2.5
	Mujer	54	1.5	0.3	2.8	0.2	12.1
	Subtotal	73	1.3	0.3	2.4	0.2	12.1
Total	Hombre	36	0.7	0.4	0.7	0.2	2.5
	Mujer	98	1.7	0.4	3.2	0.2	19.2
	Total	134	1.5	0.4	2.8	0.2	19.2

Tabla 3. GH 15 minutos.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	13.0	8.9	9.6	5.7	43.2
	Mujer	44	17.6	11.3	17.9	0.4	85.0
	Subtotal	61	16.3	10.3	16.1	0.4	85.0
Depresión	Hombre	19	7.8	2.7	13.6	0.2	55.7
	Mujer	54	9.0	2.5	14.5	0.2	54.6
	Subtotal	73	8.7	2.7	14.2	0.2	55.7
Total	Hombre	36	10.2	6.5	12.0	0.2	55.7
	Mujer	98	12.9	6.2	16.6	0.2	85.0
	Total	134	12.2	6.5	15.5	0.2	85.0

Tabla 4. GH 30 minutos.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	14.2	10.0	12.8	4.2	54.2
	Mujer	44	22.4	12.9	20.1	0.5	64.2
	Subtotal	61	20.1	10.5	18.6	0.5	64.2
Depresión	Hombre	19	9.2	3.1	14.1	0.2	51.8
	Mujer	54	11.5	2.5	17.2	0.2	58.0
	Subtotal	73	10.9	2.8	16.4	0.2	58.0
Total	Hombre	36	11.5	7.2	13.5	0.2	54.2
	Mujer	98	16.3	7.0	19.2	0.2	64.2
	Total	134	15.0	7.0	18.0	0.2	64.2

Tabla 5. GH 60 minutos.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	12.7	7.0	13.0	1.8	52.2
	Mujer	44	16.9	7.7	19.2	0.6	81.0
	Subtotal	61	15.7	7.7	17.7	0.6	81.0
Depresión	Hombre	19	7.3	2.4	10.3	0.2	35.6
	Mujer	54	15.3	2.8	32.8	0.2	202.0
	Subtotal	73	13.2	2.5	28.9	0.2	202.0
Total	Hombre	36	10.1	4.9	11.9	0.2	52.2
	Mujer	98	16.1	5.5	26.9	0.2	202.0
	Total	134	14.5	5.5	23.9	0.2	202.0

Tabla 6. GH máxima.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	16.7	11.2	12.1	5.7	54.2
	Mujer	44	25.0	15.2	21.4	1.0	85.0
	Subtotal	61	22.7	14.0	19.5	1.0	85.0
Depresión	Hombre	19	10.4	3.1	15.2	0.4	55.7
	Mujer	54	16.6	4.2	31.5	0.2	202.0
	Subtotal	73	15.0	3.9	28.2	0.2	202.0
Total	Hombre	36	13.4	8.1	14.0	0.4	55.7
	Mujer	98	20.4	8.8	27.6	0.2	202.0
	Total	134	18.5	8.8	24.9	0.2	202.0

Tabla 7. Área bajo la curva de GH.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	712.2	471.0	608.6	223.5	2652.0
	Mujer	44	1046.6	639.0	882.8	33.5	2630.2
	Subtotal	61	951.9	564.7	823.6	33.5	2652.0
Depresión	Hombre	19	483.0	187.9	664.8	13.5	2208.8
	Mujer	54	653.6	196.5	980.5	12.0	4299.8
	Subtotal	73	609.5	196.5	907.5	12.0	4299.8
Total	Hombre	36	601.1	357.5	637.1	13.5	2652.0
	Mujer	98	843.5	371.3	950.0	12.0	4299.8
	Total	134	777.9	367.9	880.6	12.0	4299.8

Tabla 8. Diferencia GH 30 min menos GH basal.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	13.25	8.30	12.72	3.40	54.00
	Mujer	44	20.33	9.90	19.99	-.20	63.70
	Subtotal	61	18.33	8.95	18.40	-.20	63.70
Depresión	Hombre	19	8.66	2.90	13.63	-.20	49.30
	Mujer	54	9.97	1.80	16.05	-2.70	49.80
	Subtotal	73	9.63	2.00	15.38	-2.70	49.80
Total	Hombre	36	10.83	6.57	13.22	-.20	54.00
	Mujer	98	14.57	5.00	18.54	-2.70	63.70
	Total	134	13.55	5.40	17.30	-2.70	63.70

Tabla 9. Diferencia GH máx menos GH basal.

Grupo	Sexo	n	Media	Mediana	D.E.	Mín.	Máx.
Control	Hombre	17	15.8	10.8	12.1	4.8	54.0
	Mujer	44	23.0	13.4	21.3	0.8	84.8
	Subtotal	61	21.0	12.3	19.3	0.8	84.8
Depresión	Hombre	19	9.9	2.9	14.8	0.0	53.2
	Mujer	54	15.1	3.0	30.9	0.0	200.6
	Subtotal	73	13.7	2.9	27.6	0.0	200.6
Total	Hombre	36	12.7	7.7	13.7	0.0	54.0
	Mujer	98	18.7	7.3	27.2	0.0	200.6
	Total	134	17.0	7.4	24.4	0.0	200.6

Figura 1

Figura 2

Figura 3

Figura 4

Figura 5

Tabla 10. Diferencias entre grupo control y depresión


Parámetro	Subgrupo	N	Media	D.E.	t	p	Difer.	IC 95 %
GH basal (ng/ml)
	Control	61	1.7	3.1	0.9	0.4	0.4	-0.5 a 1.4
Depresión
73	1.3	2.4
GH 15 min (ng/ml)
	Control	61	16.3	16.1	2.9	0.004	7.6	2.4 a 12.8
Depresión
73	8.7	14.2
GH 30 min (ng/ml)
	Control	60	20.1	18.6	3.0	0.003	9.2	3.1 a 15.2
Depresión
73	10.9	16.4
GH 60 min (ng/ml)
	Control	61	15.7	17.7	0.6	0.6	2.5	-6 a 11.1
Depresión
62	13.2	28.9
GH máx. (ng/ml)
	Control	61	22.7	19.5	1.8	0.07	7.7	-0.8 a 16.2
Depresión
73	15.0	28.2
ABC de GH (ng/ml x min)
	Control	60	951.9	823.6	2.2	0.03	342.3	31.4 a 653.3
Depresión
62	609.5	907.5
Dif. GH30 y GH0 (ng/ml)
	Control	60	18.3	18.4	3.0	0.004	8.7	2.9 a 14.5
Depresión
73	9.6	15.4
Dif. GHmax y GH0 (ng/ml)
	Control	61	21.0	19.3	1.7	0.09	7.3	-1 a 15.6
Depresión
73	13.7	27.6

Multivariant analysis

The figure following sample the distribution of the value of GH in
depressive controls and based on the age and sex. We observed that the
behavior of this answer presents/displays, in the women, greater
dispersion in inferior ages to 40 years. For that reason we have
studied the behavior separately according to were greater or smaller
of that age

Figura 6

Figura 7

The relation between the depression and the value of GH to the
different times studied by means of multiple linear regression. The
significant variables were the age (categorizada in two values:
inferior to 40 years or age equal or superior to 40 years). The
results in table 11 are detailed.

Tabla 11. GH basal

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	0.6	0.2	0.8	0.2	2.5
		Depresión	10	0.7	0.4	0.7	0.2	2.5
		Subtotal	19	0.6	0.3	0.7	0.2	2.5
	>=40	Control	8	1.3	1.5	0.7	0.2	2.2
		Depresión	9	0.4	0.2	0.3	0.2	0.8
		Subtotal	17	0.8	0.8	0.7	0.2	2.2
	Total edades	Control	17	0.9	0.8	0.8	0.2	2.5
		Depresión	19	0.5	0.3	0.6	0.2	2.5
		Subtotal	36	0.7	0.4	0.7	0.2	2.5
Mujer	<40	Control	27	2.9	0.7	4.4	0.2	19.2
		Depresión	23	2.7	1.4	3.8	0.2	12.1
		Subtotal	50	2.8	0.7	4.1	0.2	19.2
	>=40	Control	14	0.5	0.2	0.5	0.2	1.6
		Depresión	29	0.6	0.2	1.1	0.2	5.7
		Subtotal	43	0.6	0.2	0.9	0.2	5.7
	Total edades	Control	41	2.1	0.6	3.7	0.2	19.2
		Depresión	52	1.5	0.3	2.8	0.2	12.1
		Subtotal	93	1.8	0.5	3.2	0.2	19.2
Ambos sexos	Total edades	Control	61	1.7	0.6	3.1	0.2	19.2
		Depresión	73	1.3	0.3	2.4	0.2	12.1
		Total	134	1.5	0.4	2.8	0.2	19.2

Tabla 11. GH 15 minutos.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	12.2	7.1	11.8	6.4	43.2
		Depresión	10	12.1	3.8	17.9	0.2	55.7
		Subtotal	19	12.2	6.8	14.9	0.2	55.7
	>=40	Control	8	13.8	13.1	7.0	5.7	23.0
		Depresión	9	3.0	2.0	2.1	1.0	6.4
		Subtotal	17	8.1	5.7	7.4	1.0	23.0
	Total edades	Control	17	13.0	8.9	9.6	5.7	43.2
		Depresión	19	7.8	2.7	13.6	0.2	55.7
		Subtotal	36	10.2	6.5	12.0	0.2	55.7
Mujer	<40	Control	27	22.7	15.4	20.2	0.4	85.0
		Depresión	23	17.7	9.7	19.0	0.4	54.6
		Subtotal	50	20.4	13.2	19.6	0.4	85.0
	>=40	Control	14	7.0	6.8	4.5	0.4	14.3
		Depresión	29	2.3	1.6	1.9	0.2	6.9
		Subtotal	43	3.8	2.3	3.7	0.2	14.3
	Total edades	Control	41	17.4	10.7	18.1	0.4	85.0
		Depresión	52	9.1	2.5	14.7	0.2	54.6
		Subtotal	93	12.7	5.3	16.8	0.2	85.0
Ambos sexos	Total edades	Control	61	16.3	10.3	16.1	0.4	85.0
		Depresión	73	8.7	2.7	14.2	0.2	55.7
		Total	134	12.2	6.5	15.5	0.2	85.0

Tabla 12. GH 30 minutos.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	13.2	8.5	15.7	4.2	54.2
		Depresión	10	14.6	7.6	18.0	0.2	51.8
		Subtotal	19	13.9	7.6	16.5	0.2	54.2
	>=40	Control	8	15.3	11.5	9.4	4.3	30.0
		Depresión	9	3.2	2.8	1.2	1.9	5.3
		Subtotal	17	8.9	5.0	8.9	1.9	30.0
	Total edades	Control	17	14.2	10.0	12.8	4.2	54.2
		Depresión	19	9.2	3.1	14.1	0.2	51.8
		Subtotal	36	11.5	7.2	13.5	0.2	54.2
Mujer	<40	Control	27	28.7	22.1	21.3	1.3	64.2
		Depresión	23	21.9	13.4	21.6	0.3	58.0
		Subtotal	50	25.5	16.3	21.5	0.3	64.2
	>=40	Control	14	8.8	7.0	6.9	0.5	23.5
		Depresión	29	2.9	1.9	3.0	0.2	11.9
		Subtotal	43	4.8	2.3	5.4	0.2	23.5
	Total edades	Control	41	21.7	11.2	20.0	0.5	64.2
		Depresión	52	11.3	2.5	17.2	0.2	58.0
		Subtotal	93	15.8	6.8	19.1	0.2	64.2
Ambos sexos	Total edades	Control	61	20.1	10.5	18.6	0.5	64.2
		Depresión	73	10.9	2.8	16.4	0.2	58.0
		Total	134	15.0	7.0	18.0	0.2	64.2

Tabla 13. GH 60 minutos.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	14.8	8.7	15.6	3.2	52.2
		Depresión	10	11.3	6.8	12.5	0.2	35.6
		Subtotal	19	13.0	7.8	13.8	0.2	52.2
	>=40	Control	8	10.4	6.0	9.7	1.8	26.4
		Depresión	9	2.2	2.1	0.4	1.6	2.9
		Subtotal	17	6.6	2.4	8.1	1.6	26.4
	Total edades	Control	17	12.7	7.0	13.0	1.8	52.2
		Depresión	19	7.3	2.4	10.3	0.2	35.6
		Subtotal	36	10.1	4.9	11.9	0.2	52.2
Mujer	<40	Control	27	22.0	13.0	21.2	0.6	81.0
		Depresión	23	29.6	11.0	44.8	0.2	202.0
		Subtotal	50	25.3	12.0	33.4	0.2	202.0
	>=40	Control	14	5.3	4.5	3.6	1.0	11.8
		Depresión	29	2.7	1.0	3.0	0.2	9.7
		Subtotal	43	3.7	2.5	3.5	0.2	11.8
	Total edades	Control	41	16.3	7.7	19.0	0.6	81.0
		Depresión	52	15.5	2.8	33.5	0.2	202.0
		Subtotal	93	15.9	5.5	27.3	0.2	202.0
Ambos sexos	Total edades	Control	61	15.7	7.7	17.7	0.6	81.0
		Depresión	73	13.2	2.5	28.9	0.2	202.0
		Total	134	14.5	5.5	23.9	0.2	202.0

Tabla 14. GH máxima.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	16.9	11.2	15.0	6.8	54.2
		Depresión	10	16.6	7.6	19.3	0.4	55.7
		Subtotal	19	16.7	11.0	16.9	0.4	55.7
	>=40	Control	8	16.4	14.4	8.9	5.7	30.0
		Depresión	9	3.6	2.9	1.5	2.1	6.4
		Subtotal	17	9.6	5.7	8.9	2.1	30.0
	Total edades	Control	17	16.7	11.2	12.1	5.7	54.2
		Depresión	19	10.4	3.1	15.2	0.4	55.7
		Subtotal	36	13.4	8.1	14.0	0.4	55.7
Mujer	<40	Control	27	31.8	28.8	22.8	2.4	85.0
		Depresión	23	32.9	16.7	43.1	0.4	202.0
		Subtotal	50	32.3	19.1	33.3	0.4	202.0
	>=40	Control	14	10.1	8.2	6.4	1.0	23.5
		Depresión	29	3.6	2.2	3.3	0.2	11.9
		Subtotal	43	5.7	3.9	5.4	0.2	23.5
	Total edades	Control	41	24.4	15.0	21.5	1.0	85.0
		Depresión	52	16.6	4.2	32.0	0.2	202.0
		Subtotal	93	20.0	8.8	28.0	0.2	202.0
Ambos sexos	Total edades	Control	61	22.7	14.0	19.5	1.0	85.0
		Depresión	73	15.0	3.9	28.2	0.2	202.0
		Total	134	18.5	8.8	24.9	0.2	202.0

Tabla 15. ABC de GH.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	706.3	444.8	748.3	264.0	2652.0
		Depresión	10	740.8	327.4	809.3	13.5	2208.8
		Subtotal	19	723.6	437.6	756.4	13.5	2652.0
	>=40	Control	8	718.9	522.3	454.4	223.5	1432.5
		Depresión	9	151.5	121.5	61.1	95.3	239.3
		Subtotal	17	454.1	239.3	436.7	95.3	1432.5
	Total edades	Control	17	712.2	471.0	608.6	223.5	2652.0
		Depresión	19	483.0	187.9	664.8	13.5	2208.8
		Subtotal	36	601.1	357.5	637.1	13.5	2652.0
Mujer	<40	Control	27	1363.0	1386.8	916.7	152.8	2630.2
		Depresión	23	1201.6	763.1	1224.7	16.1	4299.8
		Subtotal	50	1290.9	858.0	1056.1	16.1	4299.8
	>=40	Control	14	387.8	281.2	249.6	33.5	882.8
		Depresión	29	151.2	116.2	134.8	12.0	452.2
		Subtotal	43	240.7	218.3	217.1	12.0	882.8
	Total edades	Control	41	1021.7	616.1	883.9	33.5	2630.2
		Depresión	52	652.5	196.5	994.3	12.0	4299.8
		Subtotal	93	828.3	367.9	955.9	12.0	4299.8
Ambos sexos	Total edades	Control	61	951.9	564.7	823.6	33.5	2652.0
		Depresión	73	609.5	196.5	907.5	12.0	4299.8
		Total	134	777.9	367.9	880.6	12.0	4299.8

Tabla 16. Diferencia GH a los 30 minutos menos GH basal.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	12.6	6.6	15.8	4.0	54.0
		Depresión	10	13.9	7.0	17.5	-0.2	49.3
		Subtotal	19	13.3	6.7	16.3	-0.2	54.0
	>=40	Control	8	14.0	10.3	9.1	3.4	27.8
		Depresión	9	2.8	2.6	1.0	1.7	4.5
		Subtotal	17	8.1	4.2	8.3	1.7	27.8
	Total edades	Control	17	13.3	8.3	12.7	3.4	54.0
		Depresión	19	8.7	2.9	13.6	-0.2	49.3
		Subtotal	36	10.8	6.6	13.2	-0.2	54.0
Mujer	<40	Control	27	25.7	15.4	21.9	1.1	63.7
		Depresión	23	19.2	11.9	20.5	-2.7	49.8
		Subtotal	50	22.6	14.8	21.3	-2.7	63.7
	>=40	Control	14	8.3	6.5	7.0	-0.2	23.3
		Depresión	29	2.3	1.4	3.1	-1.2	11.7
		Subtotal	43	4.2	2.0	5.4	-1.2	23.3
	Total edades	Control	41	19.6	9.2	19.8	-0.2	63.7
		Depresión	52	9.8	1.8	16.1	-2.7	49.8
		Subtotal	93	14.0	4.9	18.4	-2.7	63.7
Ambos sexos	Total edades	Control	61	18.3	9.0	18.4	-0.2	63.7
		Depresión	73	9.6	2.0	15.4	-2.7	49.8
		Total	134	13.6	5.4	17.3	-2.7	63.7

Tabla 17. Diferencia GH máxima menos GH basal.

Sexo	Subgrupo edad	Subgrupo diagn.	n	Media	Mediana	D.E.	Mín	Máx.
Hombre	<40	Control	9	16.3	10.8	15.2	6.5	54.0
		Depresión	10	15.9	7.0	18.7	0.0	53.2
		Subtotal	19	16.1	8.7	16.7	0.0	54.0
	>=40	Control	8	15.1	13.1	8.6	4.8	27.8
		Depresión	9	3.2	2.7	1.4	1.9	5.6
		Subtotal	17	8.8	4.8	8.4	1.9	27.8
	Total edades	Control	17	15.8	10.8	12.1	4.8	54.0
		Depresión	19	9.9	2.9	14.8	0.0	53.2
		Subtotal	36	12.7	7.7	13.7	0.0	54.0
Mujer	<40	Control	27	28.9	16.8	23.4	1.9	84.8
		Depresión	23	30.2	16.3	42.9	0.0	200.6
		Subtotal	50	29.5	16.5	33.4	0.0	200.6
	>=40	Control	14	9.6	7.8	6.5	0.8	23.3
		Depresión	29	3.0	1.6	3.2	0.0	11.7
		Subtotal	43	5.2	2.9	5.5	0.0	23.3
	Total edades	Control	41	22.3	12.4	21.3	0.8	84.8
		Depresión	52	15.1	3.0	31.4	0.0	200.6
		Subtotal	93	18.3	7.2	27.5	0.0	200.6
Ambos sexos	Total edades	Control	61	21.0	12.3	19.3	0.8	84.8
		Depresión	73	13.7	2.9	27.6	0.0	200.6
		Total	134	17.0	7.4	24.4	0.0	200.6

Tabla 18. Efecto de la depresión sobre el resultados de la prueba de GHRH. Resultados del estudio mediante regresión lineal múltiple. Se detalla el modelo resultante y el efecto de la depresión.

Parámetro	Modelo resultante	R2 aj.	F	p	Efecto debido a depresión
Parámetro	Modelo resultante	R2 aj.	F	p	Efecto medio	IC 95 %	p
GH basal (ng/ml)	GH0= 0.7+0.2xE+2.1S-2.4xSxE-0.2D	0.12	5.2	0.001	-0.2	-1.1 a 0.7	0.7 (N.S.)
GH 15 min (ng/ml)	GH15= 14.8-4.1xE+7.9xS-11.4xSxE-5.0xD	0.22	9.8	<0.001	-5.0	-9.9 a –0.1	0.045
GH 30 min (ng/ml)	GH30= 17.1-5.0xE+11.2xS-14.4xSxE-6.0xD	0.27	12.5	<0.001	-6.0	-11.4 a –0.6	0.03
GH 60 min (ng/ml)	GH60= 21.9-17.5E+0.2D	0.12	8.6	<0.001	0.2	-8.2 a 8.5	0.97 (N.S.)
GH máx. (ng/ml)	GHm= 18.5-7.1xE+15.4S-18.8xSxE-3.4D	0.20	9.2	<0.001	-3.4	-11.3 a 4.6	0.4 (N.S.)
ABC GH (ng/mlxmin)	ABCGH= 826.8-276.4xE+556.3S-737.7xSxE-206.5D	0.26	11.3	<0.001	-206.5	-487.2 a 74.2	0.1 (N.S.)
Dif. GH30-GH0 (ng/ml)	DifGH30_0= 16.3-5.2xE+9.0S-12.0xSxE-5.8D	0.23	10.3	<0.001	-5.8	-11.2 a –0.4	0.04
Dif GHmax – GH basal (ng/ml)	DifGHm_0= 27.6-19.1xE-3.7D	0.15	12.6	<0.001	-3.7

Study by means of stratified analysis.

The layers defined by the variables study sex and age codified
according to is of greater or equal age to 40 years or minors of this
age. Since in the men difference in relation to the age, and yes in
the women is not observed, the men in all the ages analyze themselves
on the one hand and the women according to are greater or smaller of
40 years. By to be number smaller of 30 meaning has established by
means of analysis non-parametric (Mann-Whitney), that only allows to
find one p, but not to establish the magnitude of the difference nor
its interval of confidence.

Men

Parámetro	Grupo	N	Media	D.E.	p
GH basal (ng/ml)	Control	17	0.9	0.8	0.1
GH basal (ng/ml)	Depresión	19	0.5	0.6	0.1
GH 15 min (ng/ml)	Control	17	13.0	9.6	0.001
GH 15 min (ng/ml)	Depresión	19	7.8	13.6	0.001
GH 30 min (ng/ml)	Control	17	14.2	12.8	0.006
GH 30 min (ng/ml)	Depresión	19	9.2	14.1	0.006
GH 60 min (ng/ml)	Control	17	12.7	13.0	0.03
GH 60 min (ng/ml)	Depresión	16	7.3	10.3	0.03
GH máxima (ng/ml)	Control	17	16.7	12.1	0.003
GH máxima (ng/ml)	Depresión	19	10.4	15.2	0.003
ABC de GH (ng/ml x min)	Control	17	712.2	608.6	0.009
ABC de GH (ng/ml x min)	Depresión	16	483.0	664.8	0.009
Dif. GH 30 m menos GH basal (ng/ml)	Control	17	13.3	12.7	0.006
Dif. GH 30 m menos GH basal (ng/ml)	Depresión	19	8.7	13.6	0.006
Dif. GH max menos GH basal (ng/ml)	Control	17	15.8	12.1	0.003
Dif. GH max menos GH basal (ng/ml)	Depresión	19	9.9	14.8	0.003

Women of less than 40 years:

Parámetro	Grupo	N	Media	D.E.	p
GH basal (ng/ml)	Control	27	2.9	4.4	0.9
GH basal (ng/ml)	Depresión	23	2.7	3.8	0.9
GH 15 min (ng/ml)	Control	27	22.7	20.2	0.3
GH 15 min (ng/ml)	Depresión	23	17.7	19.0	0.3
GH 30 min (ng/ml)	Control	26	28.7	21.3	0.1
GH 30 min (ng/ml)	Depresión	23	21.9	21.6	0.1
GH 60 min (ng/ml)	Control	27	22.0	21.2	0.7
GH 60 min (ng/ml)	Depresión	21	29.6	44.8	0.7
GH máxima (ng/ml)	Control	27	31.8	22.8	0.3
GH máxima (ng/ml)	Depresión	23	32.9	43.1	0.3
ABC de GH (ng/ml x min)	Control	26	1363.0	916.7	0.3
ABC de GH (ng/ml x min)	Depresión	21	1201.6	1224.7	0.3
Dif. GH 30 m menos GH basal (ng/ml)	Control	26	25.7	21.9	0.1
Dif. GH 30 m menos GH basal (ng/ml)	Depresión	23	19.2	20.5	0.1
Dif. GH max menos GH basal (ng/ml)	Control	27	28.9	23.4	0.2
Dif. GH max menos GH basal (ng/ml)	Depresión	23	30.2	42.9	0.2

Women of age equal or superior to 40 years:

Parámetro	Grupo	N	Media	D.E.	p
GH basal (ng/ml)	Control	14	0.5	0.5	0.6
GH basal (ng/ml)	Depresión	29	0.6	1.1	0.6
GH 15 min (ng/ml)	Control	14	7.0	4.5	<0.001
GH 15 min (ng/ml)	Depresión	29	2.3	1.9	<0.001
GH 30 min (ng/ml)	Control	14	8.8	6.9	0.002
GH 30 min (ng/ml)	Depresión	29	2.9	3.0	0.002
GH 60 min (ng/ml)	Control	14	5.3	3.6	<0.001
GH 60 min (ng/ml)	Depresión	23	2.7	3.0	<0.001
GH máxima (ng/ml)	Control	14	10.1	6.4	<0.001
GH máxima (ng/ml)	Depresión	29	3.6	3.3	<0.001
ABC de GH (ng/ml x min)	Control	14	387.8	249.6	0.004
ABC de GH (ng/ml x min)	Depresión	23	151.2	134.8	0.004
Dif. GH 30 m menos GH basal (ng/ml)	Control	14	8.3	7.0	0.002
Dif. GH 30 m menos GH basal (ng/ml)	Depresión	29	2.3	3.1	0.002
Dif. GH max menos GH basal (ng/ml)	Control	14	9.6	6.5	<0.001
Dif. GH max menos GH basal (ng/ml)	Depresión	29	3.0	3.2	<0.001

If we considered only the people with greater or equal age to 40
years:

Parámetro	Subgrupo	N	Media	Mediana	D.E.	Mín.	Máx	t	p	Difer.	IC 95 %
GH basal (ng/ml)	Control	22	0.8	0.7	0.7	0.2	2.2	1.3	0.2	0.3	-0.2 a 0.8
GH basal (ng/ml)	Depresión	38	0.5	0.2	1.0	0.2	5.7	1.3	0.2	0.3	-0.2 a 0.8
GH 15 min (ng/ml)	Control	22	9.5	8.3	6.3	0.4	23.0	6.4	<0.001	7.1	4.9 a 9.3
GH 15 min (ng/ml)	Depresión	38	2.4	1.7	1.9	0.2	6.9	6.4	<0.001	7.1	4.9 a 9.3
GH 30 min (ng/ml)	Control	22	11.2	8.5	8.3	0.5	30.0	5.6	<0.001	8.2	5.3 a 11.1
GH 30 min (ng/ml)	Depresión	38	3.0	2.0	2.7	0.2	11.9	5.6	<0.001	8.2	5.3 a 11.1
GH 60 min (ng/ml)	Control	22	7.2	5.3	6.8	1.0	26.4	3.4	0.001	4.7	1.9 a 7.4
GH 60 min (ng/ml)	Depresión	38	2.5	1.9	2.7	0.2	9.7	3.4	0.001	4.7	1.9 a 7.4
GH máx. (ng/ml)	Control	22	12.4	9.4	7.8	1.0	30.0	6.2	<0.001	8.8	6 a 11.6
GH máx. (ng/ml)	Depresión	38	3.6	2.5	3.0	0.2	11.9	6.2	<0.001	8.8	6 a 11.6
ABC de GH (ng/ml x min)	Control	22	508.2	396.7	366.0	33.5	1432.5	5.0	<0.001	356.9	213.5 a 500.3
ABC de GH (ng/ml x min)	Depresión	38	151.3	121.1	120.6	12.0	452.2	5.0	<0.001	356.9	213.5 a 500.3
Dif. GH30 y GH0 (ng/ml)	Control	22	10.3	7.9	8.1	-0.2	27.8	5.5	<0.001	7.9	5 a 10.8
Dif. GH30 y GH0 (ng/ml)	Depresión	38	2.4	1.8	2.8	-1.2	11.7	5.5	<0.001	7.9	5 a 10.8
Dif. GHmax y GH0 (ng/ml)	Control	22	11.6	8.5	7.6	0.8	27.8	6.2	<0.001	8.5	5.8 a 11.3
Dif. GHmax y GH0 (ng/ml)	Depresión	38	3.1	2.3	2.9	0.0	11.7	6.2	<0.001	8.5	5.8 a 11.3

Being the so large inferior sample to 30 (and not being fulfilled the
condition of normality) we cannot apply the t of Student, reason why
we would be like before.

Â Behavior of the controls:

Â Basal GH: relation with any variable was not observed.

Parámetro	Modelo	R2 ajustada	F	p	Efecto de sexo femenino	Efecto de edad³40 años
GH basal	Ninguno				N.S.	N.S.
GH 15 min	GH15= 20.1-10.6xE	0.09	6.4	0.01	N.S.	-10.6 (-2.2 a –20.0) p=0.01
GH 30 min	GH30= 13.2+15.5xS+2.1xE-22.0xSxE	0.18	5.2	0.003	<40a: 15.5 (2.6 a 28.3), p=0.02 ³40a: -6.5 (-21.3 a 8.3), p=0.4, N.S.	hombres: 2.1 (-14.1 a 18.3) p=0.8, N.S. mujeres: -19.8 (-30.9 a –8.8) p=0.001
GH 60 min	GH60= 20.2–13.0xE	0.12	8.7	0.005	N.S.	-13.0 (-21.9 a –4.2) p=0.005
GH máxima	GHmax= 16.9+14.9xS-0.5xE-21.2xSxE	0.19	5.5	0.002	<40a: 14.9 (1.4 a 28.3), p=0.03 ³40a: -6.3 (-21.8 a 9.2), p=0.4, N.S.	hombres: -0.5 (-17.5 a 16.5) p=1.0, N.S. mujeres: -21.7 (-33.2 a –10.1) p=0.0004
ABC de GH	ABCGH= 706.3+656.7xS+12.6xE-987.8xSxE	0.22	6.2	0.001	<40a: 656.7 (95.5 a 1217.9), p=0.02 ³40a: -331.1 (-974.3 a 312.1), p=0.3, N.S.	hombres: 12.6 (-692.6 a 717.7) p=1.0, N.S. mujeres: -975.2 (-1456.3 a –494.2) p=0.0002
Dif GH 30 min menos Gh basal	DifGH30_0= 22.3-12.0xE	0.09	6.5	0.01	N.S.	-12.0 (-21.4 a –2.6) p=0.01
Dif. GH máx menos GH basal	Dif GHm_0= 25.8-14.2xE	0.12	8.4	0.005	N.S.	-14.2 (-21.0 a –4.4) p=0.005

Tiempo máximo de GH


		Frequency	Percent	Valid Percent	Cumulative Percent
Valid
2.00	24	39.3	39.3	39.3

3.00	28	45.9	45.9	85.2

4.00	9	14.8	14.8	100.0

Total	61	100.0	100.0

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